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The blaze broke out around 4:35 p.m. Tuesday, Dec. 28 in Massapequa Park.
Responders arrived on Eastlake Avenue and discovered the home fully engulfed in flames, Nassau County Police said.
The Massapequa Fire Department extinguished the fire, and rescued a 58-year-old man from the basement, police said.
Police said the man was transported to a local area hospital and is in critical condition.
Two other residents of the home were also transported to local area hospitals for smoke inhalation and are expected to recover.
One firefighter was treated by medics at the scene for exhaustion.
The Nassau County Fire Marshal is investigating.
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